Optimising glucocorticoid replacement in adrenal insufficiency


  • Karim Meeran Imperial College, London




prednisolone, Addison’s disease, hydrocortisone, cortisol, pituitary, fludrocortisone


Several different regimens for steroid replacement have been tried, but head to head studies of different treatments need to be more widely undertaken. Once daily treatment with prednisolone gives the most physiological profile, and studies comparing prednisolone with hydrocortisone are now being undertaken. It is likely that prednisolone 4mg daily will be the optimum treatment used.


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