Wernicke’s encephalopathy following tirzepatide therapy in a non-alcoholic patient with autoimmune hepatitis/primary biliary cholangitis and diabetes: a case report

Authors

  • Yasmin Zaidy RCGP

DOI:

https://doi.org/10.15277/bjd.2026.502

Keywords:

Wernicke’s encephalopathy, GLP-1/GIP receptor agonist, tirzepatide, case report, optic neuropathy, thiamine deficiency

References

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Yu AT, Gross A, Park K, Harvey EJ. Wernicke encephalopathy after bariatric surgery: a literature review. Obes Surgery 2023;33:3621-7 https://doi.org/10.1007/s11695-023-06840-8.

Gras C, De Wit V, Oussedik N, et al. Semaglutide-induced Wernicke encephalopathy: a comprehensive analysis. Eur J Clin Nutr 2025; 79:1160-3. https://doi.org/10.1038/s41430-025-01653-7.

Lev D, Leibovitz A, Lang A, et al. Glucagon-like peptide-1 receptor agonists and Wernicke encephalopathy: a pharmacovigilance study and literature review. Clinical Nutrition 2026;57:106571. https://doi.org/10.1016/j.clnu.2025.106571.

Christensen S, Robinson K, Thomas S, Williams DR. Dietary intake by patients taking GLP-1 and dual GIP/GLP-1 receptor agonists: a narrative review and discussion of research needs. Obes Pillars 2024;11:100121. https://doi.org/10.1016/j.obpill.2024.100121.

Poli VFS, Sanches RB, Moraes ADS, et al. The excessive caloric intake and micronutrient deficiencies related to obesity after a long- term interdisciplinary therapy. Nutrition 2017;38:113–19. www.sciencedirect.com/science/article/pii/S089990071730031X,https://doi.org/10.1016/j.nut.2017.01.012.

Sibal R, Balamurugan G, Langley J, Graham Y, Mahawar K. Macronutrient, micronutrient supplementation and monitoring for patients on GLP-1 agonists: can we learn from metabolic and bariatric surgery? Nutrients 2025;17:3659. www.mdpi.com/2072-6643/17/23/3659, https://doi.org/10.3390/nu17233659.

Urbina Jorge, Salinas-Ruiz LE, Valenciano C, Clapp B. Micronutrient and nutritional deficiencies associated with GLP-1 receptor agonist therapy: a narrative review. Clin Obes 2026;16:e70070. pubmed.ncbi.nlm.nih.gov/41549912/, https://doi.org/10.1111/cob.70070.

Sechi G, Serra A. Wernicke’s encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol 2007;6:442–55. www.ncbi.nlm.nih.gov/pubmed/17434099,https://doi.org/10.1016/S1474-4422(07)70104-7.

Tao X, Qiao R, Liu C, et al. Wernicke encephalopathy induced by glucose infusion: a case report and literature review. Heliyon 2024; 10:e29419. https://doi.org/10.1016/j.heliyon.2024.e29419.

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Published

2026-05-18

Issue

Section

Case Reports