Factitious administration of analogue insulin to a 2-year-old child

Authors

  • Nehal Thanawala Department of Paediatrics, University Hospitals of Leicester NHS Trust, Leicester, UK
  • Sarah Cheney Department of Paediatrics, University Hospitals of Leicester NHS Trust, Leicester, UK
  • Gwen Wark Royal Surrey County Hospital NHS Foundation Trust, Guildford, Surrey, UK
  • Mario Thevis German Sport University Cologne, Center for Preventive Doping Research/Institute of Biochemistry, Cologne, Germany
  • Andreas Thomas German Sport University Cologne, Center for Preventive Doping Research/Institute of Biochemistry, Cologne, Germany
  • Webster Madira Department of Biochemistry, University Hospitals of Leicester NHS Trust, Leicester, UK
  • Vaitsa Tziaferi Department of Paediatrics, University Hospitals of Leicester NHS Trust, Leicester, UK
  • James Greening Department of Paediatrics, University Hospitals of Leicester NHS Trust, Leicester, UK

DOI:

https://doi.org/10.15277/bjd.2016.080

References

Lebowitz MR, Blumenthal SA. The molar ratio of insulin to C-peptide: an aid to the diagnosis of hypoglycemia due to surreptitious (or inadvertent) insulin administration. Arch Intern Med 1993;153:650–5. http://dx.doi.org/10.1001/archinte.1993.00410050082011

Thomas A, Schänzer W, Delahaut P, Thevis M. Sensitive and fast identification of urinary human, synthetic and animal insulin by means of nano-UPLC coupled with high resolution/high accuracy mass spectrometry. Drug Test Anal 2009;1:219. http://dx.doi.org/10.1002/dta.35

Thomas A, Schänzer W, Thevis M. Determination of human insulin and its analogues in human blood using liquid chromatography coupled to ion mobility mass spectrometry (LC-IM-MS). Drug Test Anal 2014; 6:1125–32. http://dx.doi.org/10.1002/dta.1710

Thevis M, Thomas A, Delahaut P, Bosseloir A, Schänzer W. Qualitative determination of synthetic analogues of insulin in human plasma by immunoaffinity purification and liquid chromatography-tandem mass spectrometry for doping control purposes. Anal Chem 2005;77:3579-85. http://dx.doi.org/10.1021/ac050066i

Giurgea I, Ulinski T, Touati G, et al. Factitious hyperinsulinism leading to pancreatectomy: severe forms of Munchausen syndrome by proxy. Paediatrics 2005;116;e145. http://dx.doi.org/10.1542/peds.2004-2331

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Published

2016-06-12

Issue

Vol. 16 No. 2 (2016)

Section

Case Reports

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